She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. What Are the Side Effects of Milk Thistle? Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). No supplement is intended to treat, cure, or prevent disease. Milk thistle (PDQ) patient version. Natural Medicines website. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. We explore the potential health benefits of milk thistle below. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. This publication is not copyrighted and is in the public domain. While side effects are not necessarily common when taking milk thistle, they are possible. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. Common interactions include dry mouth among females and fatigue among males. Eur Endocrinol. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Take this product by mouth as directed. Milk thistle may interact with certain medications. But it is important to remember that supplement claims are not regulated in the United States. J Diabetes Res. It also looks at how to use milk thistle and whether there are any risks to consider. Vegetable Oil: Nutrition Fac Olive Oil Vs. Studies show that silymarin may help ease inflammation and promote cell repair. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. nausea, loss of appetite. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Enter other medications to view a detailed report. Milk thistle. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Milk thistle had no effect on any of the drugs. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. It also seems to have antioxidant and anti-inflammatory effects. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. Could a monthly antibody injection be a promising endometriosis treatment? This document does not contain all possible interactions. hepatitis. List Milk Thistle Capsule side effects by likelihood and severity. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Vegetable Oil: Nutrition Facts And Differences. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Milk Thistle; Silybum marianum; St. Mary's Thistle. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. Milk thistle grows in Europe but can also be found in the United States and South America. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. gallbladder disorders. We include products we think are useful for our readers. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. US residents can call their local poison control center at 1-800-222-1222. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. The following two tabs change content below. Other studies looking at milk thistle for cirrhosis have found conflicting results. An important part of taking supplements is proper storage. 3 are moderate, and 1 is minor. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. This stout thistle usually grows in dry, sunny areas. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. Email this report to a friend, doctor, or patient. This is not a complete list of side effects and others may occur. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. It may take one or two weeks for milk thistle to start working. Do not double the dose to catch up. You can learn more about how we ensure our content is accurate and current by reading our. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. If you miss a dose, take it as soon as you remember. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Avoid combinations; the risk of the interaction outweighs the benefit. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. There are 4 drugs known to interact with The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Last medically reviewed on December 17, 2021. Cymbalta side effects (more detail) People can purchase milk thistle supplements in health food stores or online. Milk thistle may help strengthen a persons immune response. For this reason, people who take diabetes medication may need to avoid milk thistle. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. We avoid using tertiary references. Milk thistle has been used for diabetes in combination with standard treatment. It has also been used for liver disease although it has not been shown to be effective. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Milk thistle could play an essential role in supporting bone health. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. World J Gastroenterol. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. WebMD does not provide medical advice, diagnosis or treatment. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. However, the extracts in milk thistle could act like estrogen. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). jaundice. Gillessen A, Schmidt HH. Biomed Res Int. Silymarin is an active compound found in milk thistle seeds. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. The name milk thistle is associated with the legend of Mother Mary. National Center for Complementary and Integrative Health. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Refer to storage information printed on the package. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. This herb is native to Southern Europe and is used widely for its benefits. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Milk thistle comes in many forms, including tea. Keep all medications and herbal products away from children and pets. Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. This article will explore the potential uses of milk thistle. 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